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KMID : 0379520000160020101
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한국독성학회지
2000 Volume.16 No. 2 p.101 ~ p.107
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Antitumor Evaluation of Cannabidiol and Its Derivatives by Colorimetric Methods
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Baek Seung-Hwa
Shin Ji-Hee
Chung Woo-Young
Han Du-Seok
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Abstract
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Cannabidiol derivatives (1, 2 and 3), 5-fluorouracil (4, 5-FU) and adriamycin (5, AM) were tested for their growth inhibitory effects against human tumor cell lines using two different 3-{4,5-dimeth-ylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and sulforhodamine B protein (SRB) assay. The light microscopic study showed morphological changes of the treated cells. Disruptions in cell organelles were determined by colorimetric methods; MTT assay and STB assay. These results suggest that cannabidiol (1, CBD) retains the most growth-inhibitory activity against human tumor cell lines.
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KEYWORD
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Cannabidiol, 5-Fluorouracil, Adriamycin, Growth-inhibitory activity, Cytotoxic effect, KB cell lines, SK-MEL-3 cell lines, MTT assay, SRB assay
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